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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but they are unheard of In this particular malignancy compared to other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A can also be mutated in a small proportion of individuals. O